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. 2010 Sep 7;59(12):3198–3207. doi: 10.2337/db10-0195

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Ebselen reduces diabetes-associated atherosclerosis in the ApoE^−/−GPx1^−/− (dKO) aorta. Sudan IV-stained aortas from (A) nondiabetic, (B) diabetic, and (C) ebselen-gavaged diabetic dKO mice, 20 weeks after sham or streptozotocin-induced diabetes. Total and regional plaque is shown in D and E, respectively; Bars, mean ± SEM (n = 6–10 aortas/group). ***P < 0.001, **P < 0.01 vs. nondiabetic controls; ###P < 0.001, ##P < 0.01, #P < 0.05 vs. diabetic dKO aortas. Abd, abdominal; D, diabetic; Eb, ebselen; ND, nondiabetic; Thor, thoracic. (A high-quality digital representation of this figure is available in the online issue.)