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. 2010 Sep 7;59(12):3198–3207. doi: 10.2337/db10-0195

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Ebselen attenuates ApoE^−/−GPx1^−/− (dKO) aortic protein levels after 10 weeks of STZ-induced diabetes. Representative immunhistochemical staining for each protein is shown in supplementary online Fig. 2A–F. Quantitation of immunohistochemical staining within aortic sections is shown for (A) Nox2, (B) nitrotyrosine (NT), (C) 4-HNE, (D) VEGF, (E) CTGF, and (F) VCAM-1. Values are expressed relative to the nondiabetic dKO group which is arbitrarily assigned a value of 1. Bars, mean ± SEM n = 5–7 aortas/group; *P < 0.05 vs. nondiabetic dKO group; #P < 0.05 vs. diabetic dKO group. a.u., arbitrary units; D, diabetic; Eb, ebselen; NT, nitrotyrosine; ND, nondiabetic.