Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 7;59(12):3198–3207. doi: 10.2337/db10-0195

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 5. — The H₂O₂-mediated increase in nitrotyrosine (NT) is reduced by ebselen in the diabetic ApoE^−/−GPx^−/− (dKO) kidney. A–D: Representative photomicrographs of kidney tubules after 20 weeks of diabetes. (A) nondiabetic dKO, (B) diabetic dKO, (C) diabetic dKO + Eb, and (D) negative control which consisted of species-matched nonimmune IgG in place of primary antibody. E–H: Representative photomicrographs of kidney glomeruli after 20 weeks of diabetes. Nondiabetic dKO (E); Diabetic dKO (F); diabetic dKO + Eb (G); and negative control which consisted of species-matched nonimmune IgG in place of primary antibody (H). Quantitation of nitrotyrosine-stained tubules and glomeruli is shown in I and J, respectively. ***P < 0.001; diabetic dKO versus diabetic ApoE^−/− kidneys. ##P < 0.01 and ###P < 0.001 vs. diabetic dKO kidneys. Bars, mean ± SEM; n = 6–8 kidneys/group. a.u., arbitrary units; D, diabetic; Eb, ebselen; ND, nondiabetic. (A high-quality digital representation of this figure is available in the online issue.)