TABLE 1.
Enrichments in plasma glucose after 200–230 min of [6,6-2H2]glucose infusion as a percentage of enrichment at 240 min (11:30 a.m.)*
| Time (min) | |||||
|---|---|---|---|---|---|
| Subjects | n | 200 | 210 | 220 | 230 |
| Control subjects | 7 | 98.9 ± 4.3 | 104 ± 5.5 | 99.3 ± 3.3 | 97.4 ± 3.8 |
| Diabetic subjects before metformin | 7 | 104.3 ± 4.5 | 99 ± 6.0 | 102.8 ± 3.4 | 106.8 ± 5.6 |
| Diabetic subjects after metformin | 7 | 94 ± 1.0 | 92.8 ± 3.0 | 95 ± 3.2 | 98.8 ± 2.7 |
Data are means ± SE.
*
Mean percent excess enrichments at 240 min in control subjects was 1.14%; in diabetic subjects premetformin, 0.82%; and in diabetic subjects postmetformin 1.02%.
Natural abundance was less than one-seventh of these enrichments.