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. 2010 Dec;88(6):1081–1087. doi: 10.1189/jlb.0610318

Figure 3. Type1 IFN-mediated Ch25h expression is IFNR-dependent.

Figure 3.

BMDCs (A) and BMMs (B) from WT BALB/cJ and ifnar−/− mice were stimulated with IFN-α, IFN-β, IFN-γ, or a panel of TLR ligands for 6 h, and the transcription of Ch25h was measured by real-time RT-PCR. Ch25h transcription was expressed in relative units normalized to 18S rRNA. Each bar represents the mean (sd) of the measurements from three biological replicates. The differences in Ch25h expression between WT- and ifnar−/−-derived BMDCs for poly I:C, LPS, ODN1826, IFN-α, IFN-β, and IFN-γ treatments were statistically significant at P < 0.05 (two-way ANOVA). The differences in Ch25h expression between WT- and ifnar−/−-derived BMMs for poly I:C, LPS, IFN-α, and IFN-β treatments were statistically significant at P < 0.0001 (two-way ANOVA).