Table 1.
Characteristics of induced gliomas
| High-grade glioma | Low-grade glioma | ||
|---|---|---|---|
| Key histological features | Anaplasia Mitotic activity Microvascular proliferation Pseudopallisading necrosis |
No anaplasia Minimal mitotic activity No microvascular proliferation No necrosis |
|
| Equivalent human grade | WHO grade III | WHO grade II | |
| Equivalent human pathology | Anaplastic Oligodendroglioma | Oligodendroglioma | |
|
PDGF-B murine system |
Incidence of gliomas | 19% (5/26) | 81% (21/26) |
| GFAP staining | Positive | Positive | |
| Mitotic index | 1.8% | 0.9% | |
| Bcl-2 staining | Minimal | Minimal | |
| % cells expressing p-STAT3 | 27.9 ± 11.1% | 1.0 ± 0.1% | |
| % of macrophages | 16.2 ± 1.7% | 0.5 ± 0.2% | |
| % of FoxP3 positive cells | 5.7 ± 0.1% | 3.5 ± 0.8% | |
|
PDGF-B + BCL-2 murine system |
Incidence of gliomas | 61% (20/33) | 39% (13/33) |
| GFAP staining | Positive | Positive | |
| Mitotic index | 11.0% | 1.0% | |
| Bcl-2 staining | High | Minimal | |
| % cells expressing p-STAT3 | 24.1 ± 5.4% | 2.6 ± 1.6% | |
| % of macrophages | 25.6 ± 3.8% | 1.7 ± 0.9% | |
| % of FoxP3 positive cells | 3.6 ± 0.4% | 2.8 ± 0.3% | |