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. Author manuscript; available in PMC: 2011 Nov 23.

Published in final edited form as: Circulation. 2010 Nov 8;122(21):2170–2182. doi: 10.1161/CIRCULATIONAHA.110.958033

(A) The protocol used for I/R for Tg-Sirt1 and NTg control mice in the Langendorff model. The hearts of Tg-Sirt1 or NTg control mice were subjected to 30 minutes of global ischemia and 60 minutes of reperfusion. (B-F) Hemodynamics of the Langendorff-perfused isolated mouse hearts of Tg-Sirt1 and NTg control mice. (B) LVSP, left ventricular systolic pressure; (C) LVDP, left ventricular developed pressure (systolic pressure – diastolic pressure); (D) LVEDP, left ventricular end-diastolic pressure; (E,F) Systolic and diastolic dP/dt. In B-F, the level at baseline is expressed as 100%. (G) (upper) Gross appearance of LV myocardial sections after triphenyltetrazolium chloride (TTC) staining. (lower) The infarction area/AAR (where AAR= total heart) was significantly smaller in Tg-Sirt1 than in NTg.

(A) The protocol used for I/R for Tg-Sirt1 and NTg control mice in the Langendorff model. The hearts of Tg-Sirt1 or NTg control mice were subjected to 30 minutes of global ischemia and 60 minutes of reperfusion. (B-F) Hemodynamics of the Langendorff-perfused isolated mouse hearts of Tg-Sirt1 and NTg control mice. (B) LVSP, left ventricular systolic pressure; (C) LVDP, left ventricular developed pressure (systolic pressure – diastolic pressure); (D) LVEDP, left ventricular end-diastolic pressure; (E,F) Systolic and diastolic dP/dt. In B-F, the level at baseline is expressed as 100%. (G) (upper) Gross appearance of LV myocardial sections after triphenyltetrazolium chloride (TTC) staining. (lower) The infarction area/AAR (where AAR= total heart) was significantly smaller in Tg-Sirt1 than in NTg.