Table 1. 20 week plasma biochemistry in female mice.
20-week plasma biochemistry in female FTO-2, FTO-3 and FTO-4 mice on standard diet.
All data are given as mean ±s.e.m. ALP, alkaline Phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FFA, free fatty acids; LDH, lactate dehydrogenase; CK, creatine kinase. Cholesterol, total cholesterol; HDL-C, HDL-cholesterol; LDL, LDL-Cholesterol. Bold text P<0.05
| FTO-2 | FTO-3 | FTO-4 | t test | |||
|---|---|---|---|---|---|---|
| Units | n=16 | n=28 | n=17 | FTO-2 vs FTO-3 (P=) | FTO-2 vs FTO-4(P=) | |
| ALP | U/l | 84.7 ± 6 | 86 ± 4 | 87 ± 8. | 0.8696 | 0.8173 |
| ALT | U/l | 42 ± 5. | 42 ± 4 | 70 ± 17 | 0.8913 | 0.0473 |
| AST | U/l | 134 ± 20 | 166 ± 15 | 192 ± 41 | 0.2198 | 0.1680 |
| Albumin | g/l | 30 ± 1.6 | 27 ± 0.4 | 26 ± 0.6 | 0.0229 | 0.0785 |
| Cholesterol | mmol/l | 2.4 ± 0.19 | 2.6 ± 0.13 | 2.1 ± 0.14 | 0.3435 | 0.6101 |
| HDL-C | mmol/l | 1.2 ± 0.1 | 1.6 ± 0.1 | 1.5 ± 0.1 | 0.0320 | 0.0460 |
| LDL-C | mmol/l | 0.68 ± 0.17 | 0.39 ± 0.02 | 0.33 ± 0.22 | 0.0347 | 0.0657 |
| Glucose | mmol/l | 16.8 ± 0.7 | 19.6 ± 0.8 | 15.9 ± 1.7 | 0.0137 | 0.5247 |
| Triglycerides | mmol/l | 0.69 ± 0.04 | 0.94 ± 0.06 | 0.80 ± 0.03 | 0.0074 | 0.0472 |
| Glycerol | μmol/l | 562 ± 25 | 577 ± 24 | 543 ± 19 | 0.7683 | 0.5745 |
| FFA | mmol/l | 0.82 ± 0.06 | 1.07 ± 0.06 | 1.11 ± 0.08 | 0.0273 | 0.0320 |
| LDH | U/l | 680 ± 72 | 743 ± 54 | 879 ± 122 | 0.5240 | 0.2366 |
| Amylase | U/l | 580 ± 22 | 632 ± 78 | 743 ± 109 | 0.1420 | 0.1819 |
| CK | U/l | 207 ± 38 | 367 ± 43 | 450 ± 73 | 0.0308 | 0.0147 |