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. 2010 Dec 17;54(3):508–515. doi: 10.1007/s00125-010-1993-4

Table 3.

General additive models for time trend of type 1 diabetes mellitus incidence

Models Residual deviance AIC p valuea
Base model
Null model 2,883.4
Year 1,872.8 2,487.6 <0.000001
Age* 1,343.2 1,960.0 <0.000001
Age*+Year 332.59 951.34 <0.000001
Age*+Year+Sex* 315.23 935.97 0.000031
Age*+Year+Sex*+Year:Age* 259.78 884.53 <0.000001
Age*+Year†+Sex*+Year:Age*+Age:Sex* 239.51 868.26 0.000040
Base model + geographical regionb, final model
Null model 6,396.12
Age*+Year†+Sex*+Year:Age*+Age:Sex*+Region*c 953.7 2202.8 <0.000001
Base model + population density d, final model
Null model 6,280.3
Age*+Year†+Sex+Year:Age*+Age:Sex*+Area* e 1,153.1 2,407.9 <0.000001

The AIC and p values (a) from the test of relative fit (compared with the best model in previous step) are presented for model selection

aTest of relative fit

bRegion: north, south

c+Year:Region*+Age:Region*

dArea: urban, rural

e+Year:Area*+Year:Sex+Age:Area*+Area:Sex*+Age:Area:Sex*+Year:Area:Sex*

*Significant components (p < 0.05)

Significant non-linear components (p < 0.05)