. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Trends Immunol. 2011 Feb 1;32(2):50–56. doi: 10.1016/j.it.2010.12.004

Table II.

Different types of memory phenotype CD8⁺ T cells

		Signals involved in generation		T-box transcription factor	Recall response	Innate function
		TCR	Cytokines	T-box transcription factor	Recall response	Innate function
Conventional (primed)		Foreign antigens	IL-2, IL-12, IFNα	T-bet Eomes	Yes	Yes
Non-conventional (unprimed)	Homeostatic memory	Self antigens	IL-7 (IL-15)	T-bet (?) Eomes (?)	No	Yes
Non-conventional (unprimed)	IL-4 memory (innate CD8s”)	Self antigens?	IL-4 (others?)	Eomes	No	Yes