Table 1.
Transcript origin analysis of experimentally induced transcriptional alterations in isolated leukocyte subsets
| Isolated cell type (comparison) | Mean TOA diagnosticity score | Difference from genome mean TOA score* (±SE) | P |
| Monocyte (LPS + IFN-γ vs. IL-4) | |||
| Monocyte | 1.35 | 1.15 ± 0.09 | 0.0000 |
| Dendritic cell | 0.90 | 0.49 ± 0.14 | 0.0002 |
| NK cell | 0.67 | −0.25 ± 0.17 | 0.9325 |
| CD4+ T cell | 0.15 | −0.26 ± 0.05 | 0.9999 |
| CD8+ T cell | 0.05 | −0.16 ± 0.04 | 0.9999 |
| B cell | −0.76 | 0.11 ± 0.09 | 0.1082 |
| Dendritic cell (vs. monocyte) | |||
| Monocyte | −0.25 | −0.05 ± 0.04 | 0.8980 |
| Dendritic cell | 0.22 | 0.08 ± 0.03 | 0.0040 |
| NK cell | 0.60 | 0.05 ± 0.03 | 0.0588 |
| CD4+ T cell | 0.28 | −0.05 ± 0.02 | 0.9768 |
| CD8+ T cell | 0.15 | −0.03 ± 0.02 | 0.8852 |
| B cell | −1.30 | −0.02 ± 0.04 | 0.6579 |
| NK cell (untreated vs. IL-2 + IL-15) | |||
| Monocyte | 0.33 | 0.11 ± 0.09 | 0.3468 |
| Dendritic cell | 1.23 | 0.81 ± 0.08 | 0.0392 |
| NK cell | 2.38 | 1.45 ± 0.08 | 0.0080 |
| CD4+ T cell | −0.11 | −0.49 ± 0.06 | 0.9957 |
| CD8+ T cell | −0.18 | −0.37 ± 0.06 | 0.9924 |
| B cell | −0.90 | −0.01 ± 0.10 | 0.5254 |
| T lymphocyte (untreated vs. norepinephrine) | |||
| Monocyte | 0.36 | −0.01 ± 0.07 | 0.5547 |
| Dendritic cell | 0.46 | −0.02 ± 0.08 | 0.6143 |
| NK cell | 0.75 | −0.18 ± 0.17 | 0.8522 |
| CD4+ T cell | 0.45 | 0.10 ± 0.04 | 0.0029 |
| CD8+ T cell | 0.21 | 0.07 ± 0.03 | 0.0078 |
| B cell | −0.76 | 0.05 ± 0.09 | 0.3083 |
| B lymphocyte (untreated vs. EBNA-2†) | |||
| Monocyte | −0.17 | −0.38 ± 0.27 | 0.9240 |
| Dendritic cell | 0.86 | 0.46 ± 0.38 | 0.1130 |
| NK cell | 0.69 | −0.23 ± 0.48 | 0.6818 |
| CD4+ T cell | −0.05 | −0.45 ± 0.15 | 0.9983 |
| CD8+ T cell | −0.14 | −0.34 ± 0.12 | 0.9960 |
| B cell | 1.31 | 2.19 ± 0.27 | 0.0000 |
Positive diagnosticity indicates that differentially expressed genes originate predominately from the analyzed cell type. Negative values are uninformative, implying that transcripts originate from other cell types or from the analyzed cell type as well as other cell types. TOA, Transcript Origin Analysis.
*Positive values indicate that differentially expressed genes originate from the indicated cell type. Negative values are uninformative (transcripts are not distinctive to target cell type or are distinctive to other cells).
†Epstein–Barr virus nuclear antigen 2.