Fig. 2.
Loss of endothelial fenestrae in old mice is reversed by DOI administration. (A and B) Representative scanning EM micrographs of young and old animals showing a decreased number of fenestrae in old animals. (C and D) DOI administration for 2 d every 12 h opens fenestrae in old animals. (E) Quantification of area of fenestrae per total endothelial surface area in young and old mice with and without DOI treatment before sham operation (n = 5). **P = 0.007 vs. old without DOI. (F) Number of fenestrae 48 h after partial hepatectomy with and without DOI pretreatment in old animals (n = 5). *P = 0.034 vs. without DOI.