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KYNA and glutamate in the hippocampus of KAT II knock-out (KO) mice and age-matched wild-type (WT) animals. (a) Tissue levels of KYNA in KAT II KO (N=16) and WT (N=17) mice. Data are the mean±SEM. *p<0.05 vs WT controls; basal extracellular KYNA (b) and glutamate (c) levels, respectively, in KAT II KO mice and WT mice, measured by in vivo microdialysis. Data are the mean±SEM (N=6 per group). *p<0.05 vs WT controls.
