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. Author manuscript; available in PMC: 2011 Mar 17.
Published in final edited form as: Autoimmunity. 2010 Feb;43(1):76–83. doi: 10.3109/08916930903374618

Figure 2. CpG-motif and CG-rich containing DNA fragments activate TLR9.

Figure 2

The canonical CpG motif recognized by TLR9, PuPuCGPyPy is depicted in turquoise. The strong B cell mitogen 1826, a single stranded phosphorothioate (PS-DNA) oligonucleotide (ODN), contains two repeats of the CpG motif. CG50 is an experimentally designed phosphorodiester dsDNA fragment that includes 50 repeats of the canonical CpG motif. Clone 11 is a dsDNA fragment corresponding to an endogenous CpG island that contains two CpG motifs (in turquoise) and 42 CG-repeats (in yellow). SenP1 is a DNA fragment representative of genomic DNA.