Table 2.
Allele Frequencya of Individual SNPs in Populations of Different Ancestry.
| Racec | rs12980275 A/G |
rs11881222 A/G |
rs12979860b C/T |
rs8099917 T/G |
|---|---|---|---|---|
| European | 0.66/0.34 | 0.69/0.31 | NA | 0.83/0.17 |
| African | 0.47/0.53 | 0.67/0.33 | 0.40/0.60 | 0.93/0.07 |
| Asian | 0.92/0.08 | 0.93/0.07 | 0.92/0.08 | 0.92/0.08 |
| Hispanic | 0.57/0.43 | NA | 0.56/0.44 | 0.69/0.31 |
Data are from the International HapMap Project (www.hapmap.org).
Allele frequencies are defined in each population as Protective/Risk. As illustrated by rs12979860, a protective allele may be the major variant in one population and the minor variant in another. rs8103142 and rs28416813 were not included in this table because of lack of available data.
Populations were sampled worldwide and were then summed to constitute each racial designation, as described here and defined by the International HapMap Project. European: Utah residents with Northern and Western European ancestry; Tuscan in Italy. African: African ancestry in Southwest USA; Luhya in Webuye, Kenya; Maasai in Kinyawa, Kenya; Yoruba in Ibadan, Nigeria. Asian: Han Chinese in Beijing, China; Chinese in Metropolitan Denver, Colorado; Japanese in Tokyo, Japan. Hispanic: Mexican ancestry in Los Angeles, California.
Allele frequencies for rs12979860 were more completely tested and are presented in Fig. 4.
NA-allele frequencies not available