Fig. 7.
VSD signals evoked in CA3 and CA1 by mossy fiber stimulation show frequency-dependent facilitation and were enhanced in Mecp2 mutant slices. A: representative examples of the spatiotemporal pattern of VSD signals evoked in area CA3 (red arrow) and CA1 (white arrow) by stimulation of afferent mossy fibers in slices from a symptomatic Mecp2 mutant mouse and a wild-type littermate. Asterisk shows the location of the stimulating electrode. Ventral hippocampal slices with stimulation electrodes in CA3 s. lucidum to stimulate afferent mossy fibers. Note the red LEDs marking the hexagonal photodiode array. B: amplitude and spatiotemporal pattern of VSD signals evoked in area CA3 by mossy fiber stimulation. C: amplitude and spatiotemporal pattern of VSD signals evoked in area CA1 by mossy fiber stimulation. Data are means ± SD. *P < 0.05, Student's t-test of symptomatic vs. wild-type.