Fig. 8.
Adenosine prevents hyperexcitability in area CA1 of Mecp2 mutant slices. A: representative examples of the spatiotemporal pattern of VSD signals evoked in area CA1 by stimulation of afferent Schaffer collaterals in slices from a symptomatic Mecp2 mutant mouse and a wild-type littermate before and after the application of adenosine (50 μM). Arrow points to the location of the stimulation electrode. B: amplitude and spatiotemporal pattern of VSD signals evoked in area CA1 by stimulation of afferent Schaffer collaterals in the presence of adenosine in slices from symptomatic Mecp2 mutant and wild-type littermate controls. Data are means ± SD. *P < 0.005, aCSF vs. adenosine in wild-type slices by ANOVA; **P < 0.005, aCSF vs. adenosine in Mecp2 mutant slices by ANOVA; #P < 0.05 Mecp2 mutant vs. wild-type slices in aCSF by ANOVA.