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Two-dimensional scatter plot comparing pNFH levels versus C3 levels in the CSF of each subject. Most control subjects with high levels of C3 exhibit low levels of pNFH. The lines illustrate the thresholds cut-off values generated from the ROC curves in Figure 4. Increased sensitivity for ALS is generated by ALS cases that lie below pNFH=0.635 but above the pNFH/C3=0.000125 line.
