Table 1.
Pharmaceutical drugs found to increase PON1 activity/expression in animals or Humans
| Drugs | PON1 increase | Reference |
|---|---|---|
| Cardiovascular drugs | ||
| Statins (simvastatin, atorvastatin)* | 5–23% | [17–20, 25] |
| Fibrates (Gemfibrozil, fenofibrate)* | 18–59% | [23, 29] |
| Probucol | 50% | [36] |
| Ezetimibe | 32% | [37] |
| Aspirin* | 13% | [32, 34] |
| Antidiabetic drugs | ||
| Rosiglitazone | 10–67% | [38–40] |
| Eplerenone | 60% | [41] |
| Sulphonylureas (glimepiride, glibenclamide) | 28–64%** | [42] |
| Other drugs | ||
| Erythropoietin beta | 23% | [48] |
*
Studies with these drugs have provided contrasting results. See text for details.
**
Increase only in liver, decrease in plasma [42].