Table 4.
Colorectal cancer (stage I-III) mortality by level of post-diagnosis physical activity in strata of nuclear CTNNB1 (β-catenin) status
| Nuclear CTNNB1 (−) |
Nuclear CTNNB1 (+) |
P for interaction |
|||
|---|---|---|---|---|---|
| MET-hours /week <18 |
MET-hours /week ≥18 |
MET-hours /week <18 |
MET-hours /week ≥18 |
||
| Colorectal cancer-specific mortality | |||||
| No. of events/No. at risk | 33/168 | 6/92 | 16/140 | 13/97 | |
| Five-year survival | 0.89 | 0.97 | 0.93 | 0.94 | |
| Age-adjusted event incidence rate | 0.019 | 0.006 | 0.012 | 0.013 | |
| Univariate HR (95% CI) | 1 (referent) | 0.31 (0.13-0.73) | 1 (referent) | 1.14 (0.55-2.37) | 0.024 |
| Stage-matched HR (95% CI) | 1 (referent) | 0.33 (0.14-0.79) | 1 (referent) | 1.09 (0.53-2.28) | 0.040 |
| Multivariate stage-matched HR (95% CI) |
1 (referent) | 0.33 (0.13-0.81) | 1 (referent) | 1.07 (0.50-2.30) | 0.046 |
| Overall mortality | |||||
| No. of events/No. at risk | 67/168 | 25/92 | 51/140 | 33/97 | |
| Five-year survival | 0.85 | 0.90 | 0.84 | 0.91 | |
| Age-adjusted event incidence rate | 0.040 | 0.027 | 0.037 | 0.032 | |
| Univariate HR (95% CI) | 1 (referent) | 0.60 (0.38-0.95) | 1 (referent) | 0.89 (0.57-1.38) | 0.22 |
| Stage-matched HR (95% CI) | 1 (referent) | 0.61 (0.38-0.97) | 1 (referent) | 0.85 (0.55-1.33) | 0.30 |
| Multivariate stage-matched HR (95% CI) |
1 (referent) | 0.68 (0.42-1.09) | 1 (referent) | 0.86 (0.55-1.34) | 0.47 |
The multivariate stage-matched (stratified) Cox regression model included the same set of covariates selected as in Table 2. CI, confidence interval; HR, hazard ratio; MET, metabolic equivalent task.