Table 2.
Cases from the UK-Alzheimer’s Disease Centre, Nun Study and Georgia Centenarians: comparison in TDP-43 immunostaining including 79 cases (convenience sample) with hippocampal sclerosis (HS-Ageing) and 227 patients without hippocampal sclerosis (HS-NEG)
| Cohort | Total stained for TDP-43 (n) | Average age at death (years) | HS-Ageing evaluated for TDP-43 (n) | HS-Ageing with TDP+n (%) | HS-NEG evaluated for TDP-43 (N) | HS-NEG with TDP+n (%) |
|---|---|---|---|---|---|---|
| UK-Alzheimer’s Disease Centre | 208 | 84.3 | 23 | 15 (65) | 185 | 15 (5) |
| Nun Study | 48 | 92.8 | 48 | 43 (90) | ||
| Georgia centenarians | 50 | 102.2 | 8 | 8 (100) | 42 | 7 (17) |
| Total | 306 | 88.6 | 79 | 66 (89.9) | 227 | 22 (9.7) |