Table 5.
UPD lesions detected by SNP-A and affected candidate genes (N = 26)
| Patient no. | Disease | Chromosome | Start | Stop | Length, Mb | Affected candidate genes |
|---|---|---|---|---|---|---|
| 22 | AP | 5q22.1q33.3 | 110815528 | 157807809 | 46.99 | APC, IRF1, TCF7, SKP1, CDKL3, PHF15, TIFAB, GFRA3, JMJD1B, ETF1, NRG2, HBEGF, ANKHD1, SRA1, HDAC3, NDFIP1, SPRY4, FGF1, ARHGAP26, NR3C1, TCERG1, PPP2R2B, PPARGC1B, CSF1R, PDGFRB, CDX1, RPS14, IRGM, ANXA6, FAT2, SPARC, ATOX1, G3BP1, HAND1, MRPL22, MED7, SOX30, CLINT1 |
| 22 | AP | 8q21.2q24.3 | 87129788 | 146263890 | 59.13 | WWP1, RIPK2, MTG8, GEM, RAD54B, GDF6, RPL30, STK3, YWHAZ, GRHL2, RRM2B, UBR5, BAALC, FZD6, ZFPM2, EIF3E, EBAG9, CSMD3, TRPS1, EIF3H, MED30, SAMD12, TNFRSF11B, NOV, ENPP2, TAF2, DSCC1, ZHX1/2, ANXA13, MYC, WISP1, Cap43, NDRG1, ST3GAL1, CHRAC1, PTK2, PTP4A3, BAI1, JRK, MAFA, MAPK15, PUF60, FBXL6, NFKBIL2, RECQL4 |
| 44 | Myeloid BP | 11p15.5p12 | 194228 | 41346378 | 41.15 | DUSP8, RASSF7, H19, IGF2, ASCL2, TSSC4, CDKN1C, NAP1L4, NUP98, RRM1, ILK, TPP1, NLRP10, STK33, ST5, WEE1, SBF2, AMPD3, MRVI1, EIF4G2, DKK3, TEAD1, ARNTL, RRAS2, SOX6, PTPN5, BBOX1, LGR4, METT5D1, ELP4, PAX6, WT1, HIPK3, COMMD9, TRAF6 |
| 44 | Myeloid BP | 17q11.2q25.3 | 27492835 | 78640854 | 51.15 | Whole 17q |
AP indicates accelerated phase; and BP, blast phase.