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. 2011 Jun;188(2):435–447. doi: 10.1534/genetics.111.127068

TABLE 3.

Estimated QTL effects in simulated F2

Regression on QTL genotypes
 Regression on line dosagesa
Simulated effects Ordinary QTL vQTL Ordinary QTL vQTL
No QTL 0.001 −0.003 0.008 0.001
Ordinary QTL 1.997 −0.003 2.063 0.023
vQTL −0.010 0.2175 −0.004 0.238
Ordinary and vQTL 1.999 0.2173 1.913 0.247

Simulated value for mean-controlling QTL, 2.0; simulated value for variance-controlling QTL, 0.22.

a

Estimates from genome scan with regression on line dosages. Correction for shrunken line dosage estimates in HAPPY due to low marker information contents; corrected values = estimates from genome scan times half the range of line dosages.