Table 1.
Factors correlated with neutralization breadth
Variable | Univariate model |
Multivariate model 1 |
Multivariate model 2 |
|||
---|---|---|---|---|---|---|
Estimate (95% CI) | P valuea | Estimate (95% CI) | P valuea | Estimate (95% CI) | P valuea | |
Viral load | ||||||
6 mo | 0.11 (0.077, 0.143) | 0.0020 | 0.124 (0.071, 0.178) | 0.0259 | 0.032 (−0.008, 0.073) | 0.4308 |
12 mo | 0.077 (0.040, 0.114) | 0.0437 | −0.005 (−0.065, 0.055) | 0.9366 | ||
36 mo | 0.044 (0.008, 0.080) | 0.2219 | −0.045 (−0.096, 0.006) | 0.3836 | ||
Viral load AUC | 0.080 (0.043, 0.117) | 0.0389 | 0.026 (−0.045, 0.098) | 0.7145 | ||
Preinfection CD4 countb | 0.016 (0.008, 0.024) | 0.0710 | ||||
CD4 declineb | 0.024 (0.015, 0.032) | 0.0094 | 0.021 (0.030, 0.011) | 0.0474 | ||
CD4 count | ||||||
6 mo | −0.029 (−0.046, −0.012) | 0.0998 | ||||
12 mo | −0.024 (−0.041, −0.007) | 0.1564 | ||||
36 mo | −0.021 (−0.037, −0.005) | 0.1923 |
Statistically significant P values are shown in bold.
Data are available for only 21 of the 40 study participants.