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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Oct 26;1813(9):1593–1606. doi: 10.1016/j.bbamcr.2010.10.014

Fig. 2.

Fig. 2

Structures of Kapβ2 bound to PY-NLSs. (A) Structure of Kapβ2 (red) bound to the PY-NLS of hnRNP A1 (green); PDB 2H4M [18]. (B) PY-NLSs of hnRNP A1 (green) and hnRNP M (magenta) upon superposition of the Kapβ2s. Epitopes 1 (N-terminal hydrophobic/basic motifs), 2 and 3 (C-terminal Rx(2–5)PY motif) structurally converge and are separated by structurally diverse linkers. (C) Sequences of the PY-NLSs in (B) and the consensus sequences.