Table 6.
Nuclear import cargos of Importin-7, Importin-β/Importin-7 heterodimer and Importin-8.
| Cargo | Location of NLS | Other Kapβs that also mediate import |
|---|---|---|
|
Importin-7 | ||
| Proline-rich homeodomain [147] | Homeodomain | |
| EZI [93] | Zinc fingers 9–12 | |
| dpERK [206,207] | Not determined | |
| ERK-2 [95] | 10-residue SPS region | |
| MEK1 [95] | SPS region | |
| Smad3 [95] | SPS region | |
| HIV-1 Integrase [81,82,89,90] | Residues 212-288 | Importin-α/β [85–87,90], -β, -β/-7, Trn-SR2 [83,84,88] |
| CDK5 activator p35 [76] | Not determined | Importin-β, -5 |
| HIF1-α [53] | PAS domain | Importin-4 |
| c-Jun [77] | Residues 250-334 | Kapβ2, Importin-β, -5, -9 |
| Glucocorticoid receptor [78] | Not determined | Importin-α/β, Kap108p |
| HIV-1 Rev [79] | Residues 35-46 | Kapβ2, Importin-β, -5 |
| rPL23a [50] | Residues 32-74 | Kapβ2, Importin-α/β, -β, -5 |
| rPS7, rPL5 [50] | Not determined | Kapβ2, Importin-α/β, -β, -5 |
| H2A, H2B, H3, H4 [67,68] | Not determined | Kapβ2, Importin-α/β (H2B only), -β, -5, -9 |
|
Importin-β/-7 heterodimer | ||
| H1 [54,91] | Full length protein | |
| HIV-1 Integrase [81,82,89,90] | Importin-α/β [85-87], -β, -7, Trn-SR2 [83,84,88] | |
| Adenovirus core protein pVII [80] | Residues 82-198 | Kapβ2, Importin-α/β, -β, -7 |
| rPL6 [54] | Importin-β, -7, -9 | |
| rPL4 [54] | Importin-β, -9 | |
| rPS3a [54] | Importin-4, -5 | |
|
Importin-8 | ||
| Ago2 [97] | ||
| Smad4 [96] | Includes residues 1-63 | |
| Smad1 [96] | ||
| NPM-ALK [99] | Kapβ2 | |
| SRP19 [98] | Kapβ2, Importin-8;-β, -5, -7 (weak) | |