Table 2. Lipid classes, species and their mass levels in Alzheimer and control subjectsa.
Lipid Class | # of Species | ControlMean ± SD | ADMean ± SD | P |
PC | 65 | 30±9 | 25±5.1 | 0.022 |
PE | 86 | 1.66±0.54 | 1.53±0.52 | 0.41 |
PI | 25 | 0.51±0.15 | 0.44±0.15 | 0.11 |
SM | 33 | 9.35±3.78 | 7.33±2.38 | 0.026 |
LPC | 14 | 2.57±0.70 | 2.41±0.59 | 0.39 |
Ceramide | 29 | 0.21±0.08 | 0.23±0.07 | 0.26 |
Free.Chol. | 1 | 16±6.2 | 16±6 | 0.85 |
Chol.Ester | NA | 32±13 | 32±13 | 0.96 |
TAG | >500 | 11.6±5.5 | 13.5±6.0 | 0.24 |
SD denotes standard deviation. P values were computed by Welch two-sample t-test. All the results are obtained by shotgun lipidomics as described under Materials and Methods and presented in unit of nmol/mg protein. See text for abbreviations.