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Calmodulin-dependent transcriptional pathways for cardiac hypertrophy. Activated calcineurin has been shown to act through NFAT3, which associates with GATA4, to induce hypertrophy (12). Activated CaMK stimulates transcriptional activity of MEF2 through a posttranslational mechanism. Calcineurin only weakly activates MEF2 in the heart (indicated by a broken line).
