Table 3.
Mid-diaphyseal pQCT scans of femora in adult mice
|
|
Wild type (n = 6)
|
TRα1−/−β−/− (n = 6)
|
Difference (%)a
|
|---|---|---|---|
| Cortical density (mg/mm3) | 1.301 ± 0.013 | 1.246 ± 0.017 | −4.2* |
| Cortical area (mm2) | 1.225 ± 0.039 | 1.031 ± 0.039 | −15.8** |
| BMC (mg/mm) | 1.596 ± 0.063 | 1.286 ± 0.057 | −19.4** |
| Cortical thickness (mm) | 0.348 ± 0.010 | 0.319 ± 0.010 | −8.3 |
| Periosteal circumference (mm) | 5.448 ± 0.084 | 5.063 ± 0.137 | −7.1* |
| Endosteal circumference (mm) | 3.360 ± 0.179 | 3.267 ± 0.119 | −2.8 |
| Cross-sectional moment of inertia (mm4) | 0.798 ± 0.029 | 0.582 ± 0.046 | −27.1** |
| Moment of resistance (mm3) | 0.665 ± 0.022 | 0.547 ± 0.025 | −17.8** |
a
(*) P < 0.05; (**) P < 0.01; vs. wild type; no asterisk indicates no significant difference (P > 0.05); determined by Student’s t-test.