Table 2.
Demographics, pathological, and clinical information about ‘CERAD[31]-positive’ cases with Braak stages V and VI pathology (evaluated within 3 years of death) in the NACC registry and the Nun Study
| Braak V | Braak VI | p value | |
|---|---|---|---|
| NACC cases, n | 568 | 651 | – |
| Adjusted* Final MMSE score, Mean ± SEM | 11.0 ± 0.4 | 8.0 ± 0.3 | <0.0001 |
| Male gender, n (%) | 282 (49.7) | 335 (51.5) | 0.53 |
| Age at death, Mean ± SEM | 83.8 ± 0.3 | 79.5 ± 0.3 | <0.0001 |
| Maximum education level in years, Mean ± SEM | 14.6 ± 0.1 | 14.2 ± 0.1 | 0.046 |
| Neocortical Lewy bodies, n (%) | 66 (11.6) | 51 (7.8) | 0.025 |
| Hippocampal sclerosis, n (%) | 58 (10.2) | 56 (8.6) | 0.36 |
| Non-demented, n (%) | 36 (6.3) | 5 (0.8) | <0.0001 |
| “Normal cognition” cases, n (%) | 15 (2.7) | 2 (0.3) | 0.0005 |
| MCI cases, n (%) | 18 (3.2) | 3 (0.5) | 0.0003 |
| Months between final evaluation and death, Mean ± SEM | 12.4 ± 0.4 | 14.8 ± 0.4 | <0.0001 |
| Nun Study cases, n | 64 | 87 | – |
| Adjusted* Final MMSE score, Mean ± SEM | 14.9 ± 1.1 | 5.8 ± 1.0 | <0.0001 |
| Male gender, n (%) | 0.0 | 0.0 | – |
| Age at death, Mean ± SEM | 91.4 ± 0.6 | 89.3 ± 0.5 | 0.0083 |
| Maximum education level in years, Mean ± SEM | 15.6 ± 0.4 | 15.0 ± 0.4 | 0.26 |
| Neocortical Lewy bodies, n (%) | 2 (3.1) | 5 (5.7) | 0.45 |
| Hippocampal sclerosis, n (%) | 8 (12.5) | 15 (17.2) | 0.42 |
| Non-demented, n (%) | 27 (42.2) | 8 (9.2) | <0.0001 |
| “Normal cognition” cases not assessed | – | – | – |
| MCI cases not assessed | – | – | – |
| Months between final evaluation and death, Mean ± SEM | 9.4 ± 0.8 | 9.8 ± 0.7 | 0.68 |
*
Adjusted for age at death and education.