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De novo and salvage pathway synthesis of dTTP. There are two distinct pathways for dTTP synthesis. In the de novo pathway, SHMT catalyzes the conversion of serine and tetrahydrofolate (THF) to methyleneTHF and glycine. TYMS converts methyleneTHF and dUMP to dihydrofolate (DHF) and dTMP. DHF is converted to THF for subsequent rounds of dTMP synthesis in an NADPH-dependent reaction catalyzed by DHFR. In the salvage pathway, thymidine is phosphorylated by TK to form dTMP.
