Fig. 4.
Repetitive marble burying and perseveration in searching for previous escape platform location in MWM and water Y-maze. (A) Marble burying: TS2-neo mice buried twice as many marbles as WT littermates during a 30-min exposure to 20 marbles (P = 0.03, Student's t test). n (WT) = 23, n (TS2-neo) = 23. (B) MWM: during the first four trials of reversal learning, TS-neo mice spent significantly more time in previous target quadrant than WT (P < 0.03, Student's t test). n (WT) = 27, n (TS2-neo) = 29. (C) Water Y-maze: percentage of correct arm choices per trial block during acquisition (day 1 of experiment), test (day 2), reversal (day 3), and forced training (day 3). During reversal training, TS2-neo mice made significantly fewer correct choices than control mice (P = 0.02 for genotype effect, ANOVA). n (WT) = 11, n (TS2-neo) = 11. (D) Color-coded graph depicting individual trial outcomes in water Y-maze (white/green for wrong/correct arm choices, respectively). Forced training (incorrect arm blocked): three TS2-neo mice never made correct choice, whereas the WT mouse entered correct arm from first trial onward.