Table 4.
Responses of GECIs in cerebellar Purkinje cells.
| Number of complex spikes | YC2.60 (A; n = 8) | YC3.60 (B; n = 7) | YC-Nano15 (C; n = 7) | GCaMP3 (D; n = 8) | ANOVA for SNR |
|---|---|---|---|---|---|
| SNR (Peak amplitude, %) | p-value of ANOVA/Tukey’s post-hoc test | ||||
| 1 | 2.3 ± 0.8 (18 ± 8.2) | 1.1 ± 0.3 (6.8 ± 2.6) | 3.3 ± 1.6 (17 ± 7.7) | 1.0 ± 0.4 (3.2 ± 1.7) | p < 0.0001 / A > B, D; C > B, D |
| 2 | 4.2 ± 2.2 (34 ± 20) | 2.1 ± 0.4 (9.4 ± 2.8) | 6.5 ± 2.6 (33 ± 14) | 1.3 ± 0.9 (4.0 ± 3.3) | p < 0.0001 / A > D; C > B, D |
| 5 | 9.8 ± 5.6 (75 ± 43) | 3.8 ± 1.7 (17 ± 8.2) | 15 ± 7.3 (70 ± 27) | 3.3 ± 4.2 (12 ± 18) | p = 0.0006 / C > B, D |
| 10 | 14 ± 9.1 (111 ± 63) | 5.5 ± 3.6 (25 ± 16) | 21 ± 12 (102 ± 39) | 6.2 ± 9.2 (23 ± 39) | p = 0.0086 / C > B, D |
Data presented as in Table 2. The numbers of recorded cells in the table apply to 2, 5, and 10 CSs; for 1 CS, n = 17 for YC2.60, n = 11 for YC3.60, n = 12 for YC-Nano15, and n = 8 for GCaMP3.