Figure 4.
Expression of microvessel-related gene products at 2 hours after MCA occlusion in the striatum. (A) Expression of the integrin β1 subunit mRNA by microvessels in the striatum of three nonhuman primate subjects (a–c) after MCA:O (Tagaya et al, 2001). Around mini-cores of absent β1 subunit mRNA, significant upregulation of the β1 subunit gene product was observed. The cores and boundary zones of β1 subunit upregulation corresponded to the regions where cells incorporated dUTP (i.e., dUTP+) (Tagaya et al, 1997). (B) Regions of VEGF expression (black), αν subunit (gray), and expression of both products (hatched) by activated microvessels in the striata of nonhuman primates that were subject to various periods of MCA occlusion (each image represents a separate animal) (Abumiya et al, 1999). The mini-cores of integrin or VEGF expression by microvessels must also be noted. MCA, middle cerebral artery; VEGF, vascular endothelial growth factor.