Table 1.
Summary of Autoimmune Disease Association to 22 ImmGen Tissues
Immune Tissues |
SLE |
Crohn Disease |
Rheumatoid Arthritis |
|||
---|---|---|---|---|---|---|
Unconditional | Adjusting for Transitional B Subtypes | Unconditional | Adjusting for DC Subtypes | Unconditional | Adjusting for Subtypes of CD4+ Effector Memory T Cells | |
B.T1.Sp | 0.00018 | – | 0.060 | 0.12 | 0.0032 | 0.0050 |
B.T2.Sp | 0.000013 | – | 0.013 | 0.029 | 0.00041 | 0.0015 |
B.T3.Sp | 0.0000059 | – | 0.030 | 0.036 | 0.00072 | 0.0055 |
B.Fo.PC | 0.000013 | 0.23 | 0.06 | 0.04 | 0.0024 | 0.0010 |
B.Fo.Sp | 0.000022 | 0.11 | 0.0071 | 0.014 | 0.00032 | 0.0015 |
B.FrF.BM | 0.000023 | 0.82 | 0.031 | 0.021 | 0.0025 | 0.0025 |
CD19Control | 0.000013 | 0.70 | 0.011 | 0.026 | 0.00099 | 0.0025 |
T.4Mem.LN | 0.024 | 0.18 | 0.018 | 0.012 | <0.0000010 | – |
T.4Mem.Sp | 0.080 | 0.27 | 0.000061 | 0.00075 | <0.0000010 | – |
T.4Mem44h62l.LN | 0.021 | 0.05 | 0.00037 | 0.009 | <0.0000010 | – |
T.4Mem44h62l.Sp | 0.062 | 0.14 | 0.00087 | 0.032 | <0.0000010 | – |
T.4.Pa.BDC | 0.0073 | 0.019 | 0.00032 | 0.00025 | 0.0000059 | 0.017 |
T.4.Sp.B16 | 0.0016 | 0.0045 | 0.010 | 0.0090 | 0.0000078 | 0.0085 |
T.4int8+.Th | 0.05 | 0.33 | 0.00083 | 0.0015 | 0.00017 | 0.18 |
T.4Mem.Tbet..Sp | 0.61 | 0.75 | 0.020 | 0.043 | 0.00021 | 0.70 |
T.4Mem.Tbet+.Sp | 0.27 | 0.43 | 0.023 | 0.068 | 0.000012 | 0.46 |
T.4SP69+.Th | 0.08 | 0.23 | 0.0094 | 0.013 | 0.00016 | 0.17 |
T.8Mem.Tbet+.Sp | 0.27 | 0.58 | 0.041 | 0.10 | 0.00018 | 0.64 |
DC.103-11b+.PolyIC.Lu | 0.013 | 0.026 | 0.000016 | - | 0.0094 | 0.021 |
DC.103+11b-.PolyIC.Lu | 0.043 | 0.062 | 0.000069 | - | 0.13 | 0.090 |
NKT.4+.Lv | 0.16 | 0.29 | 0.00038 | 0.019 | 0.00012 | 0.010 |
NK.H-.MCMV1.Sp | 0.018 | 0.0061 | 0.00014 | 0.0073 | 0.076 | 0.33 |
Here, we list all 22 out of 223 tissues from ImmGen that obtained nominally significant association (p < 0.01) in at least one of the three autoimmune phenotypes tested. For each disease, we listed results of our analysis without any conditioning, as well as results after removing the contributions of the most significant tissues. For each tissue, we listed an association significance p value for each phenotype.