Figure 7.
Effects of NPD1 on TRPV1 currents after pretreatment of pertussis toxin (PTX) and effects AC, PKA, and MEK inhibitor on TRPV1 currents in dissociate DRG neurons. A, Effects of PTX on NPD1 inhibition of TRPV1 current. Note that PTX pretreatment (0.5 μg/ml, 18 h) abolishes NPD1's inhibitory effects on TRPV1 currents. n = 11. B, Effects of adenylyl cyclase inhibitor SQ22536 (1 and 10 μm), PKA inhibitor H89 (1 and 10 nm), MEK inhibitor U0126 (1 and 10 μm), and NPD1 (1 ng/ml) on capsaicin-induced currents.