Table 1.
Baseline Characteristics
| AD | Control | P Valuea | |
|---|---|---|---|
| Number of participants | 192 | 174 | — |
| Sex (n, %) | .0109 | ||
| Female | 96 (50.0) | 110 (63.2) | |
| Male | 96 (50.0) | 64 (36.8) | |
| Age (mean, SD) | 75.8 (8.2) | 70.7 (8.2) | <.0001 |
| Range | 54–100 | 49–93 | |
| Race/ethnicity (n, %) | .7576 | ||
| Caucasian | 150 (94.3) | 144 (93.5) | |
| Not Caucasian | 9 (5.7) | 10 (6.5) | |
| Years of education (mean, SD) | 14.4 (2.8) | 15.0 (2.5) | .0486 |
| Range | 6–20 | 8–20 | |
| MMSE (mean, SD)b | 20.7 (5.6) | 29.3 (0.91) | <.0001 |
| Range | 5–30 | 25–30 | |
| CDR global (mean, SD)c | 1.2 (0.6) | 0.0 (0.0) | <.0001 |
| 0 | 0 | 99 (100.0) | |
| 0.5 | 23 (23.2) | 0 | |
| 1 | 47 (47.5) | 0 | |
| 2 | 29 (29.3) | 0 | |
| CDR sum of boxes (mean, SD)d | 6.6 (3.6) | 0.1 (0.2) | <.0001 |
| Range | 1.5–18 | 0–1.0 | |
| CRP (µg/mL) | 2.9 (4.5) | 4.9 (7.7) | .003 |
| Log CRPe(mean, SD) | 0.3 (1.3) | 0.8 (1.2) | <.0001 |
| Range | −2.8 to 3.6 | −.21 to 3.9 |
NOTES: AD = Alzheimer disease; CDR = clinical dementia rating; CRP = C-reactive protein; MMSE = Mini-Mental State Examination.
a
P values are based on a χ2 test for categorical variables and a t test for continuous variables.
b
MMSE scores were available on 192 AD patients and 174 controls.
c
CDR global scores were available on 99 AD patients and 99 controls.
d
CDR sum of boxes scores were available on 128 AD patients and 115 controls.
e
Log transformation of CRP levels passed the Anderson-Darling test for normality with a P value of .073, therefore comparison based on t test.