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PHLPP1/2 contain consensus PDZ-motifs for binding NHERF1 PDZ domains
| NHERF1 ligand | PDZ-binding motif | Interacting NHERF1 PDZ domain | Reference |
|---|---|---|---|
| PHLPP1 | …YDTPL | PDZ1, PDZ2 | This study |
| PDGFR | …EDSFL | PDZ1 | (Maudsley et al., 2000) |
| PHLPP2 | …FDTAL | PDZ2 | This study |
| β-catenin | …FDTDL | PDZ2 | (Shibata et al., 2003) |
| PTEN | …QITKV | PDZ1 | (Takahashi et al., 2006) |
| NHERF1 | …LFSNL | PDZ2 | (Morales et al., 2007) |
Bold residues indicate the NHERF1 PDZ-binding consensus motif DT/SXL.
