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. 2011 Nov 13;60(12):3235–3245. doi: 10.2337/db11-0616

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 5. — SirT1 transcript level is inversely correlated with both BMI and adipose tissue macrophage content in humans. A: Control, obese, and severely obese subjects were stratified by BMI. Obese and severely obese subjects have decreased SirT1 expression (B) and increased macrophage content (C) in subcutaneous adipose tissue. Macrophages (CD68+ cells) within an entire section were counted by two independent observers using a light microscope. % macrophages = number of macrophages / number of adipocytes × 100. Obese and severely obese subjects have elevated HOMA-IR (D). **P < 0.01, *P < 0.05, #P < 0.10. Note: 18 of the 45 subjects examined are also being studied for the contributions of a gene polymorphism to SirT1 gene expression.