Figure 3.
The density of cortical cholinergic axonal abnormalities in the four groups of subjects. No such abnormalities were present in the youngest cases (Case # 1 and 2). A small number of such abnormalities were present in the rest of the cases below 64 years and the density of such abnormalities displayed a significant increase in non-demented old cases compared with the young (p<0.05). The density of axonal abnormalities remained constant in pathologically mild AD and was reduced in pathologically severe AD and significantly so in the entorhinal cortex and the inferior parietal lobule. Quantitative analysis was conducted on all of the cases in Table 1 except those identified by an asterisk. Y – Non-Demented Young, O – Non-Demented Old, AD-M, Pathologically Mild AD, AD-S – Pathologically Severe AD.