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. 2012 Feb 1;139(3):475–487. doi: 10.1242/dev.067314

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Fig. 2. — p57^KIP2 protein expression in proliferating precursors and postmitotic neurons during development. (A) p57^KIP2 was detected at E11.5 in cells in peripheral cortex (arrowheads) with few cells in the proliferative zone (arrows). (B) At E12.5, p57^KIP2 localized to a dense group of cells laterally, including precursors (TuJ1–) and newborn neurons (TuJ1⁺). (C-I) At E14.5, p57^KIP2+ cells increased considerably in isocortex and hippocampus (HIPP), detected on anterior (C) and mid-hemisphere (D) sections. p57^KIP2 was present (E) in TuJ1⁺ postmitotic neurons (arrows, insets) and in (F) TuJ1^– cells in proliferative zones (arrows). (G) p57^KIP2 was expressed in PCNA⁺ proliferating cells (arrows) and in (H) Pax6⁺ and (I) Tbr2⁺ cells (arrows). Arrowheads in I indicate p57^KIP2+/Tbr2^– cells. Scale bars: 25 μm in G-I; 50 μm in A,E,F; 100 μm in B; 200 μm in C,D.