Outline of the pathway of synthesis of resolvins and related mediators from EPA and DHA. COX, cyclooxygenase; HpDHA, hydroperoxydocosahexaenoic acid; HpEPE, hydroperoxyeicosapentaenoic acid; LOX, lipoxygenase; LT, leukotriene; PG, prostaglandin; Rv, resolvin; TX, thromboxane