Table 2.
Validation of differentially expressed genes in SR−/− mice identified by microarray analysis. Relative mRNA expression of genes obtained from the S1 cortex of an independent group of wild-type (WT; n=4–6) and SR−/− (n=4–6) mice was measured by qPCR. Data is expressed as geometric means ± SEM of individual expression values normalized to the housekeeping gene GAPDH using the comparative 2−ΔΔCt method.
| WT | SR−/− | ||
|---|---|---|---|
| Relative mRNA expression (%WT) |
p | ||
|
Cdkn1a (n = 6/genotype) |
100 ± 14 | 65 ± 5* | 0.036 |
|
Gadd45a (n = 6/genotype) |
100 ± 15 | 58 ± 3* | 0.016 |
|
Crem (n = 6/genotype) |
100 ± 6 | 81 ± 6* | 0.031 |
|
Ndel1 (n = 4/genotype) |
100 ± 11 | 106 ± 8 | 0.69 |
Asterisk (*) indicates significant difference from the WT group (p < 0.05).