Figure 2.
JAK Inhibitors Block NMDAR-LTD
(A–F) Representative EPSC traces (top) and pooled data (bottom) of whole-cell patch-clamp recordings illustrating the block of NMDAR-LTD by AG490 (10 μM, n = 6; A), CP690550 (1 μM, n = 5; B), JAK inhibitor I (0.1 μM, n = 6; C), and WP1066 (10 μM, n = 4; D) and the lack of effect of PP2 (10–20 μM, n = 7; E) and SU6656 (10 μM, n = 11; F) on NMDAR-LTD. Calibration bars for all traces: 25 pA/50 ms.
(G) Histogram showing the amplitude of NMDAR-LTD, plotted as a percentage of baseline, for the four JAK inhibitors and the two src family PTK inhibitors. Black bars show a significant difference compared to control NMDAR-LTD (with or without DMSO, as appropriate; n = 7 and 28, respectively), and the gray bars show no difference with control.