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. Author manuscript; available in PMC: 2012 Feb 6.
Published in final edited form as: Nat Neurosci. 2011 Jul 17;14(8):1001–1008. doi: 10.1038/nn.2866

Figure 6.

Figure 6

Enhanced mossy fiber-CA3 LTP in the Mecp2S421A;S424A/y mice. (a,b) Representative recording of field EPSP (fEPSP) amplitudes in wild type (a) and the Mecp2S421A;S424A/y (b) slices. Sample traces in each genotype represent before (1) and 40 minutes after (2) the tetanic stimulation (100 Hz, 1 s, twice with 20 s interval), and after the application of DCG-IV (3). (c) Average normalized (against baseline) amplitudes in the wild type (closed circle) and the Mecp2S421A;S424A/y (open circle) slices. Error bars represent s.e.m. Statistical analysis was done using two-way ANOVA with repeated measure. F(1,32) = 11.203, p = 0.002. (d) Average normalized (against baseline) amplitudes 40–60 minutes after the LTP induction in the wild type and the Mecp2S421A;S424A/y slices. Bar graph shows mean ± s.e.m. 18 slices from 12 Mecp2S421A;S424A/y mice and 16 slices from 11 wild type littermates were included in (c) and (d). *P < 0.05. **P < 0.01.