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. Author manuscript; available in PMC: 2012 Feb 6.
Published in final edited form as: Nat Neurosci. 2011 Jul 17;14(8):1001–1008. doi: 10.1038/nn.2866

Figure 8.

Figure 8

Altered expression of MeCP2 target genes in the hippocampus of the Mecp2S421A;S424A/y mice and increased promoter binding by the MeCP2S421A;S424A-flag protein. (a) Relative expression levels of Bdnf CDS, Bdnf E4, Bmp4, Mef2c, and Grm1 in the adult hippocampus of the wild type (closed bar) and the Mecp2S421A;S424A/y mice (open bar). n = 14 in each genotype for Bdnf CDS, Bdnf E4. n = 8 in each genotype for Bmp4, Mef2c, and Grm1. p = 0.02 for Bdnf CDS. p = 0.04 for Bdnf E4. p = 0.01 for Bmp4. p = 0.05 for Mef2c. p = 0.02 for Grm1. (b) Relative binding of the MeCP2-flag and MeCP2S421A;S424A-flag protein to the promoters of Bdnf (exon IV), Bmp4, Mef2c, and Grm1 in the adult hippocampus of the Mecp2WT-flag/y mice (closed bar) and the Mecp2S421A;S424A-flag/y mice (open bar), respectively. n = 6 in each genotype. p = 0.03 for Bdnf. p = 0.01 for Bmp4. p = 0.05 for Mef2c. p = 0.04 for Grm1. *P < 0.05. **P < 0.01.