Table 4.
—Relative Risk Estimates From Published Systematic Reviews of Studies Comparing Pharmacologic and Mechanical Prophylaxis
| Study/Year and Population | PE | Asymptomatic DVT (Any) | Asymptomatic Proximal DVT | Nonfatal Major Bleeding | ICH | Death From Any Cause |
| LDUH vs nonpharmacologic | ||||||
| Collen et al10/2008 | NA |
NA |
NA |
0.85 (0.12-5.99) |
2.11 (0.39-11.3) |
0.97 (0.13-7.37) |
| Neurosurgery | ||||||
| LMWH vs nonpharmacologic | ||||||
| Collen et al10/2008 | NA |
NA |
NA |
0.95 (0.18-5.09) |
1.97 (0.64-6.09) |
0.96 (0.47-1.96) |
| Neurosurgery | ||||||
| LMWH vs IPC | ||||||
| Collen et al10/2008 | 1.62 (0.35-7.46) |
0.79 (0.30-2.12) |
NA |
NA |
NA |
NA |
| Neurosurgery | ||||||
| LMWH vs ES | ||||||
| Collen et al10/2008 | 0.29 (0.05-1.85) |
0.60 (0.44-0.81) |
NA |
NA |
NA |
NA |
| Neurosurgery | ||||||
| Any mechanical vs LDUH or LMWH | ||||||
| Eppsteiner et al28/2010 | 1.03 (0.48-2.22) |
1.07 (0.72-1.61) |
NA |
0.43 (0.19-0.98) |
NA |
NA |
| Mixed surgery | ||||||
| Any mechanical vs LDUH | ||||||
| Eppsteiner et al28/2010 | NA |
0.71 (0.42-1.19) |
NA |
NA |
NA |
NA |
| Mixed surgery | ||||||
| Any mechanical vs LMWH | ||||||
| Eppsteiner et al28/2010 | NA |
1.80 (1.16-2.79) |
NA |
NA |
NA |
NA |
| Mixed surgery | ||||||
| IPC vs heparin | ||||||
| Vanek23/1998 | 1.04 (P = 1.0) | 0.52 (P = .01) | 0.43 (P = .06) | NA | NA | NA |
| Mixed surgery | ||||||