. 2012 Feb 29;95(4):882–891. doi: 10.3945/ajcn.111.030783

TABLE 5.

Resorptions and implants in litters derived at E11.5 from Mthfd1^gt/+ and Mthfd1^+/+ dams fed a control diet or the FCDD¹

Diet and maternal Mthfd1 genotype	No. of litters	No. of total implants	No. of implants per litter	No. of total resorptions	No. of resorptions per litter
Control
+/+	10	34	3.4 ± 0.6²	1	0.1 ± 0.1
gt/+	15	56	3.7 ± 0.6	7	0.8 ± 0.32
FCDD
+/+	16	74	4.4 ± 0.5	10	0.87 ± 0.23
gt/+	13	82	6.3 ± 0.7	10	1.3 ± 0.45
FCDD + 500 μmol hypoxanthine/L
gt/+	15	59	3.8 ± 0.5	17	1.06 ± 0.36
P-diet effect	—	—	0.004	—	0.0454
P-genotype effect	—	—	0.099	—	0.0760
P-diet × genotype effect	—	—	NS	—	NS

The main effects of Mthfd1 genotype and diet and interactions of genotype and diet on implantation rates and log-transformed resorption rates were analyzed with the use of ANOVA. Post hoc comparisons were analyzed with the use of Student's t test with Bonferroni correction for multiple testing. Analysis of implants and resorptions for the FCDD + 500 μmol hypoxanthine/L group was completed separately by comparing Mthfd1^gt/+ dams fed a control diet, an FCDD, or an FCDD + 500 μmol hypoxanthine/L with the use of ANOVA. The number of implants in the FCDD + 500 μmol hypoxanthine/L group was significantly different from that of the FCDD-alone groups (P < 0.01) but not from that of the control group (P > 0.05). E, embryonic day; FCDD, AIN93G diet deficient in folate and choline; gt, gene-trapped.

Mean ± SE (all such values).