Table I. Summary of total CD8+IFNγ+ T cell response against 28 LCMV-specific epitopes in various systems analyzed.
Mouse H-2 Haplotype | Immunogen | Total Sum Response ± SDa |
---|---|---|
H-2b | LCMV | 35 ± 20 × 106 |
H-2b | GPVNPV | 22 ± 10 × 106 |
H-2Kb−/− | LCMV | 8.1 ± 6.3 × 106* |
H-2Kb−/− | GPVNPV | 3.2 ± 2.4 × 106* |
H-2bxa | LCMV | 10 ± 2.1 × 106* |
H-2bxd | LCMV | 22 ± 11 × 106 |
H-2bxk | LCMV | 20 ± 12 × 106 |
H-2bxs | LCMV | 29 ± 19 × 106 |
H-2b | rVACV-LCMV GPC/NP/L | 1.7 ± 0.71 × 106* |
H-2b | Peptide pool | 0.08 ± 0.05 × 106* |
Cumulative CD8+IFNγ+ T cell responses to 28 LCMV-specific epitopes generated by individual peptide stimulation in IFN-γ ICCS assays. The total sum response represents an average value from individually analyzed mice (±SD) from at least two independent experiments. The statistical analysis compares values significantly different from those for the wild-type H-2b mice infected with LCMV.
p < 0.05 (Mann-Whitney t test).