Table 2.
Genes induced in the MAT1A knockout mouse
| Genes | Fold induction |
|---|---|
| Immune response genes | |
| Orosomucoid/α 1-acid glycoprotein (M12566) | 52.7 |
| Serum amyloid A1 (M17790) | 40.5 |
| Metallothionein 1 (V00835) | 20.5 |
| Histocompatibility 2, class II antigen A, α (X52643) | 19.9 |
| Major histocompatibility complex class II H2-I-A-β gene (k haplotype) (M21932) | 8.7 |
| Intracellular calcium-binding protein (MRP8) (M83218) | 8.6 |
| Metallothionein 2 (K02236) | 6.5 |
| Myeloperoxidase (X15313) | 4.0 |
| Lipopolysaccharide-binding protein (X99347) | 3.1 |
| Interleukin 10 (M37897) | 2.8 |
| IgE-binding factor (M10062) | 2.5 |
| Fas antigen (M83649) | 2.4 |
| Arachidonate 12-lipoxygenase (Y14334) | 2.3 |
| CD14 antigen (X13333) | 2.2 |
| Genes involved in cell proliferation, differentiation, and signaling | |
| Early growth response 1 (EGR01 Krox-24) (M28845) | 14.3 |
| Chromatin assembly factor-I p150 subunit (AJ132771) | 8.3 |
| Insulin-like growth factor-binding protein 5 (L12447) | 3.9 |
| Peroxisome proliferator activator receptor γ (U10374) | 3.8 |
| Guanylate nucleotide-binding protein 1 (M55544) | 3.6 |
| Heat-shock protein 86 (J04633) | 3.6 |
| Ras-related YPT-1 protein (Y00094) | 3.1 |
| TYRO protein tyrosine kinase-binding protein (AF024637) | 2.7 |
| Guanine nucleotide-binding protein, β 1 (U29055) | 2.6 |
| 10.0 | |
| DNA polymerase Z catalytic subunit (AF083464) | 2.6 |
| Protein tyrosine phosphatase (PRL-1) (U84411) | 2.5 |
| Protein phosphatase 1, catalytic subunit, β isoform (M27073) | 2.4 |
| cGMP phosphodiesterase (PDE9A*1) (AF031147) | 2.3 |
| Proliferating cell nuclear antigen (X57800) | 2.1 |
| Miscellaneous genes | |
| Cytochrome P450 17 (M64863) | 11.3 |
| Glycerol kinase (U48403) | 7.6 |
| Nicotinamide N-methyltransferase (U86108) | 7.3 |
| Peptidylglycine α-amidating monooxygenase (U79523) | 6.1 |
| Asparagine synthetase (U38940) | 5.7 |
| Lysozyme P (X51547) | 4.5 |
| Carbonic anhydrase II (M25944) | 4.5 |
| 6-phosphofructo-2-kinase/fructose-2,6- biphosphatase (X98848) | 4.1 |
| Aldehyde dehydrogenase (U96401) | 3.5 |
| Glucose-6-phosphate dehydrogenase (Z84471) | 3.3 |
| Cathepsin C (U74683) | 3.2 |
| BHMT (AF033381) | 2.8 |
| Phospholipid transfer protein (U28960) | 2.8 |